1/1/2024 0 Comments Mori jin sleeping mask![]() This explains the rationale behind applying heat to the eyelids of MGD patients as it brings the meibum in the eyelids above its phase-transition temperature, enabling it to freely flow out of the meibomian glands to comprise the outermost layer of the tear film, thereby reducing evaporation of the aqueous layer 3.Īpplication of heat and eyelid massage are considered mainstay treatments for all MGD patients. MGD patients have a phase-transition at a higher temperature of about 35 ☌ 6, 7, 8, 9. In healthy subjects, the phase-transition of meibum is about 28 ☌ (when meibum transitions from an ordered and gel-like phase to a disordered fluid-like phase) 5. The eyelids maintain about 33 ☌ under normal ambient room temperature. The treatment goal of MGD is to improve the function of the meibomian glands by opening occluded gland ducts and improve meibomian gland function 4. Dysfunction of the meibomian glands could lead to increased evaporation of the tear film and evaporative DED 1. In MGD, the amount of branched chain fatty acids and cholesterol in the meibum is increased, which results in a more waxy and viscous secretion 3. The obstruction is most likely also responsible for degeneration of the meibum. Consequently, the amount of secretion produced by the gland (meibum) is reduced. Importantly, obstruction of the meibomian gland duct can lead to ductal dilation and subsequent loss of secretory cells in the gland 3. The condition, which is associated with age, sex, hormonal disturbances and environmental factors 3, leads to tear film alterations and ocular surface disease. MGD is defined as a chronic, diffuse abnormality of the sebaceous meibomian glands, which commonly is characterized by obstruction of the glandular duct and/or changes in the quality/quantity of glandular secretion 2. Meibomian gland dysfunction (MGD) is the most common cause of dry eye disease (DED) and affects between 5 and 50% of the world’s population 1. Blephasteam and TheraPearl are equally effective in treating mild to moderate MGD in a Norwegian population after 6-months of treatment.Ĭ ID: NCT03318874 Protocol ID: 2014/1983 First registration. No difference between treatments was detected at 6 months (p = 0.11 for FBUT and p = 0.71 for OSDI), nor were there differences in the other tested parameters between the treatment groups. Baseline parameter values did not differ between the groups. Other outcome measures included ocular surface staining (OSS), Schirmer’s test, and meibomian quality and expressibility. Treatment efficacy was primarily evaluated by fluorescein breakup time (FBUT) and Ocular Surface Disease Index (OSDI) scores. ![]() Patients were examined at baseline, and at three and six months initiation of treatment. All received a hyaluronic acid based artificial tear substitute (Hylo-Comod, Ursapharm, Saarbrücken, Germany). Patients were randomly assigned to treatment with Blephasteam (n = 37) or TheraPearl (n = 33). An open label, randomized comparative trial with seventy patients (49 females, 21 males mean age 53.6 years). In this study, we aimed to compare the effects of eyelid warming treatment using either TheraPearl Eye Mask (Bausch & Lomb Inc., New York, USA) or Blephasteam (Spectrum Thea Pharmaceuticals LTD, Macclesfield, UK) in a Norwegian population with mild to moderate MGD-related DED. ![]() ![]() Meibomian gland dysfunction (MGD) is the most common cause of dry eye disease (DED).
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